We have openings for self-motivated graduate students and postdoctoral fellow!!!
News
February 25, 2021-Congratulation to Krystal and Ying whose review on Protein N-terminal Methyltion has just been accepted by Current Opinion in Chemical Biology.
February 24, 2021-Congratulation to Peal who has been awarded a 2021 Dean's Undergraduate Research Fellowship this summer.
February 24, 2021-Congratulation to Dongxing, Guangping, and Youchao whose manuscript on Structure-based Discovery of Cell-potent Peptidomimetic Inhibitors for Protein N-terminal Methyltransferase 1 has just been accepted by ACS Medicinal Chemistry Letters. Also, a big thank to Dr. Nick Noinaj, one of our favorite collaborators!
January 25, 2021-Our proposal of Development of specific and potent isoprenylcysteine carboxyl methyltransferase inhibitors in collaboration with Dr. Christine Hrycyna lab in the Chemistry department has received the funding support from Purdue Cancer Collaborative Idea Project.
January 13, 2021-Our proposal of Protein N-terminal Methyltransferase 1 in Alzheimer’s disease responded to Purdue Institute for Drug Discovery and Integrative Neuroscience joint Alzheimer's disease and other dementias RFA has received the funding Thanks for the support and we are excited about a new adventure along with Dr. Yang Yang's lab.
January 5, 2021-Congratulation to Yi-Hsun whose manuscript on development of a continuous assay for NatD has just been accepted by International Journal of Molecular Sciences! www.mdpi.com/1422-0067/22/2/594 We appreciate the support from DRUG Institute screening grant and Dr. Lan Chen.
December 15, 2020-Congratulate to Amr who has become a proud dad of a beautiful baby boy Faris.
November 23, 2020-Huang lab is very excited to welcome the newest member Emma Seipp to join our N-terminal acetyltransferase project.
November 18, 2020-Congratulation on Dr. Huang's appointment as a Showalter University Faculty Scholar. Also congratulate to our collaborator Dr. Noinaj who is also the newly appointed Showalter University Faculty Scholar. https://www.purdue.edu/newsroom/purduetoday/releases/2020/Q4/showalter-trust-selects-new-scholars,-funds-11-early-career-faculty.html
October 12, 2020-Ayad's manuscript titled "Discovery of a Potent and Dual-Selective Bisubstrate Inhibitor for Protein Arginine Methyltransferase 4/5" has been accepted by Acta Pharmaceutica Sinica B. www.sciencedirect.com/science/article/pii/S2211383520307656
Septemer 25, 2020-Dr. Huang is the research spotlight for September at Purdue Life Sciences. www.purdue.edu/research/life-sciences/newsletter/research-spotlight-rong-huang/?dlv-emuid=37a470a3-c920-415b-ab4f-1a0ee8f9b527&dlv-mlid=40205881
September 23, 2020-Congratulation to Yi-Hsun who passed her OP today to be a PhD candidate now.
September 22, 2020-Big congratulation to our alumnus Ayad who has been promoted to the Chair for the Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Iraq
September 21, 2020-Welcome Katrina to do her 2nd rotation in our lab.
September 6, 2020-Ayad's work on Discovery of a Potent and Dual-Selective Bisubstrate Inhibitor for Protein Arginine Methyltransferase 4/5 has been on on bioRxiv: https://biorxiv.org/cgi/content/short/2020.09.05.283978v1
August 24, 2020-Welcome Emma and Ryan to do their 1st rotation in our lab.
July 21, 2020-Brie's paper titled "Selective Peptidomimetic Inhibitors of NTMT1/2: Rational design, synthesis, characterization, and crystallographic studies" has been accepted by Journal of Medicinal Chemistry. Congratulate to Brie, Dongxing, Guangping, and all co-authors! https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00689
July 1, 2020-Dongxing's paper titled "Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogs" has been accepted by Journal of Medicinal Chemistry. Congratulate to Dongxing and all co-authors! https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00770
June 15, 2020-Congratulate to Iredia whose manuscript titled "Development of fluorescence polarization-based competition assay for nicotinamide N-methyltransferase" has been accepted by Analytical Biochemistry. https://pubmed.ncbi.nlm.nih.gov/32622979/
June 12, 2020-Farewell to Dr. Nazimuddin who will join Boston University for a new postdoc position to fight COVID-19.
June 11, 2020- Guangping's paper on "Optimization of high-throughput methyltransferase assays for the discovery of small molecule inhibitors" has been accepted for publication in ACS Combinatorial Science. This is a team work with NCATS. Congratulation. https://pubs.acs.org/doi/10.1021/acscombsci.0c00077
May 27, 2020-Congratulate to Dr. Huang who has been appointed as a Purdue University Faculty Scholar. An additional congratulation to being selected as a 2020 Showalter Faculty Scholar. Thanks for the support from MCMP department and College of Pharmacy.
May 13, 2020-Congratulate to Ying who passed her OP to be a PhD candidate now.
May 11, 2020-Congratulate to Ayad and Krystal whose review is in press now. 10.2174/1389203721666200507091952.
April 27, 2020-Farewell to Dr. Zhi Huang who will join UNC for his new postdoc position.
February 26, 2020- We are hiring a new postdoc fellow.
link: https://career8.successfactors.com/sfcareer/jobreqcareer?jobId=9952&company=purdueuniv&username=
February 21, 2020 - We thank NIGMS for a research diversity supplement to fund our first year graduate student Krystal Diaz for 18 months.
December 19, 2019- Congratulate to Guangping who passed his OP to be a PhD candidate now.
December 10, 2019- Welcome two MCMP graduate students Amr and Krystal to join Huang lab.
November 13, 2019-Another J Med Chem paper has just been accepted today. Congratulation to Dongxing, Linjie, Krystal, and Iredia! Special appreciation to our great collaborators Dr. Nick Noinaj and his student Ravi Yadav!
October 24, 2019- Welcome Dr. Nazimuddin from University of Louisville joining our group.
October 17, 2019-Dr. Huang gave a talk at the Department of Medicinal & Biological Chemistry in University of Toledo.
October 4, 2019-Dr. Huang presented our work on protein N-terminal methylation at 2019 Protein N-termini meeting. Enjoyed the interactions in the protein N-terminal community.
September 24, 2019- Welcome Amr Elkabbany to do his 2nd rotation in the lab.
September 23, 2019- Dr. Huang gave a talk at the Department of Biochemistry and Molecular Biology in Indiana University School of Medicine.
September 2, 2019- Dr. Huang gave a talk at Baylor Medical College Department of Pharmacology & Chemical Biology.
September 2, 2019- Welcome Dr. Youchao Deng from Central South University joining our group.
August 26, 2019- Welcome Krystal to do her 1st rotation in the lab.
August 9, 2019- Our first lab retreat is a blast with various research presentations followed by hiking and kayaking.
August 5, 2019- Welcome Dr. Zhi Huang from Naikai University joining our group.
July 1, 2019 - We thank NIGMS for a supplementary award to purchase a live cell imager to boost our cell-based studies.
June 3, 2019 - Dr. Dongxing Chen presents his work on potent and selective NTMT1 inhibitors at Gordon Research Conference on High Throughput Chemistry and Chemical Biology.
May 1, 2019- Welcome Dr. Iredia D. Iyamu from Northwestern University joining our group.
April 30, 2019- Congratulation to our undergraduate student Yuanrui Zhao who has been selected as a recipient for the OUR Scholars Program.
April 15, 2019- Congratulation to visiting student Congyu Zhang who has been accepted to the PK/PD Master program in University of Buffalo in Fall 2019.
March 18, 2019 - Congratulation to Dongxing and Guangping whose first co-author paper titled "Discovery of bisubstrate inhibitor for protein N-terminal methyltransferase 1" has been accepted for publication in the Journal of Medicinal Chemistry. pubs.acs.org/doi/10.1021/acs.jmedchem.9b00206
January 25, 2019 - Congratulation to Krystal who has been admitted to MCMP PhD program starting in Fall, 2019.
January 14, 2019 - Welcome Congyu Zhang from Shenyang Pharmaceutical University and Yuanrui Zhang from Purdue University to do their undergraduate research in Huang lab.
December 5, 2018- Happy to welcome our new MCMP PhD students Ying Meng and Yi-Hsun Ho to the Huang Lab.
November 26, 2018- Dr. Huang's invited review titled "Chemical Biology of Protein N-terminal Methyltransferases" is in press in the ChemBioTalents Issue of ChemBiochem. onlinelibrary.wiley.com/doi/10.1002/cbic.201800615
November 2, 2018 -Guangping's co-first author paper on NTMT2 structure is in press now. https://www.nature.com/articles/s42003-018-0196-2
October 29, 2018 - Congratulation to Dr. Huang on her 2018 Purdue University Seed for Success Award
October 15, 2018 - Congratulation to Guangping whose first co-author paper on NTMT2 structure has been accepted for publication in Communications Biology.
October 2, 2018 - Welcome Krystal from Penn State Univ joining Huang lab as a lab technician.
August 6, 2018 - Congratulate to Pahul, our undergraduate alumnus, who just started her MD/PhD study at Univ. of Texas at Houston.
July 2, 2018 - Dr. Huang gave an invited talk at Huazhong Technology & Science University.
June 28, 2018 - Dr. Huang gave a seminar at Peking University School of Pharmaceutical Sciences, China.
June 26, 2018 - Dr. Huang gave an invited talk at Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, China.
June 19, 2018 - Our proposal of Discovery of Small Molecule Inhibitors for N-terminal Acetyltransferase D has received the Purdue Institute for Drug Discovery’s Hit to Lead Program’s High-Throughput/High-Content Chemical Genomics Screening Facility Fund. Thanks for the support and we are excited about a new adventure.
June 11, 2018 - Another co-crystal structure of our inhibitor in complex with NTMT1. Hooray for Dongxing and Nick!
May 17, 2018 - Our first provisional patent application on protein N-terminal methyltransferase peptidomimetic inhibitors has been successfully filed. Congratulate to Dongxing and Guangping! inventions.prf.org/innovation/6782
April 24, 2018 - Congratulation to Dongxing who obtained crystal structures with two of our inhibitors. Appreciate our collaborator Nick for his great effort. Can't wait to see the final structures.
March 16, 2018 - Very proud of Pahul who did her undergraduate studies with us for three years and continues to be successful. https://news.vcu.edu/article/In_Norway_Fulbright_scholar_Pahul_Hanjra_is_furthering_our_understanding?utm_source=VCUNewsNewsletter&utm_medium=email&utm_campaign=VCUNewsNewsletter&utm_content=news.vcu.edu%2Farticle%2FIn_Norway_Fulbright_scholar_Pahul_Hanjra_is_furthering_our_understanding
January 10, 2018 - Welcome Mr. Nathan J Becker joining our lab to carry his undergraduate research.
January 8, 2018 - Welcome Dr. Ayad Al-Hamashi joining our lab from University of Toledo.
August 18, 2017 - Dr. Huang has received a U01 grant from the National Cancer Institute. Thanks for the support and our collaborators at NCATS!
August 16, 2017 - We are recruiting for Two Postdoctoral Research Associate Positions. Details see www.nature.com/naturejobs/science/jobs/621777-postdoctoral-research-associate
August 15, 2017 - Linjie, Dongxing, and Guangping presented their research at PULSe retreat.
July 3, 2017 - Huang lab has moved to the 2nd floor of Purdue Institute of Drug Discovery at Purdue University.
February 24, 2021-Congratulation to Peal who has been awarded a 2021 Dean's Undergraduate Research Fellowship this summer.
February 24, 2021-Congratulation to Dongxing, Guangping, and Youchao whose manuscript on Structure-based Discovery of Cell-potent Peptidomimetic Inhibitors for Protein N-terminal Methyltransferase 1 has just been accepted by ACS Medicinal Chemistry Letters. Also, a big thank to Dr. Nick Noinaj, one of our favorite collaborators!
January 25, 2021-Our proposal of Development of specific and potent isoprenylcysteine carboxyl methyltransferase inhibitors in collaboration with Dr. Christine Hrycyna lab in the Chemistry department has received the funding support from Purdue Cancer Collaborative Idea Project.
January 13, 2021-Our proposal of Protein N-terminal Methyltransferase 1 in Alzheimer’s disease responded to Purdue Institute for Drug Discovery and Integrative Neuroscience joint Alzheimer's disease and other dementias RFA has received the funding Thanks for the support and we are excited about a new adventure along with Dr. Yang Yang's lab.
January 5, 2021-Congratulation to Yi-Hsun whose manuscript on development of a continuous assay for NatD has just been accepted by International Journal of Molecular Sciences! www.mdpi.com/1422-0067/22/2/594 We appreciate the support from DRUG Institute screening grant and Dr. Lan Chen.
December 15, 2020-Congratulate to Amr who has become a proud dad of a beautiful baby boy Faris.
November 23, 2020-Huang lab is very excited to welcome the newest member Emma Seipp to join our N-terminal acetyltransferase project.
November 18, 2020-Congratulation on Dr. Huang's appointment as a Showalter University Faculty Scholar. Also congratulate to our collaborator Dr. Noinaj who is also the newly appointed Showalter University Faculty Scholar. https://www.purdue.edu/newsroom/purduetoday/releases/2020/Q4/showalter-trust-selects-new-scholars,-funds-11-early-career-faculty.html
October 12, 2020-Ayad's manuscript titled "Discovery of a Potent and Dual-Selective Bisubstrate Inhibitor for Protein Arginine Methyltransferase 4/5" has been accepted by Acta Pharmaceutica Sinica B. www.sciencedirect.com/science/article/pii/S2211383520307656
Septemer 25, 2020-Dr. Huang is the research spotlight for September at Purdue Life Sciences. www.purdue.edu/research/life-sciences/newsletter/research-spotlight-rong-huang/?dlv-emuid=37a470a3-c920-415b-ab4f-1a0ee8f9b527&dlv-mlid=40205881
September 23, 2020-Congratulation to Yi-Hsun who passed her OP today to be a PhD candidate now.
September 22, 2020-Big congratulation to our alumnus Ayad who has been promoted to the Chair for the Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Iraq
September 21, 2020-Welcome Katrina to do her 2nd rotation in our lab.
September 6, 2020-Ayad's work on Discovery of a Potent and Dual-Selective Bisubstrate Inhibitor for Protein Arginine Methyltransferase 4/5 has been on on bioRxiv: https://biorxiv.org/cgi/content/short/2020.09.05.283978v1
August 24, 2020-Welcome Emma and Ryan to do their 1st rotation in our lab.
July 21, 2020-Brie's paper titled "Selective Peptidomimetic Inhibitors of NTMT1/2: Rational design, synthesis, characterization, and crystallographic studies" has been accepted by Journal of Medicinal Chemistry. Congratulate to Brie, Dongxing, Guangping, and all co-authors! https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00689
July 1, 2020-Dongxing's paper titled "Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogs" has been accepted by Journal of Medicinal Chemistry. Congratulate to Dongxing and all co-authors! https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00770
June 15, 2020-Congratulate to Iredia whose manuscript titled "Development of fluorescence polarization-based competition assay for nicotinamide N-methyltransferase" has been accepted by Analytical Biochemistry. https://pubmed.ncbi.nlm.nih.gov/32622979/
June 12, 2020-Farewell to Dr. Nazimuddin who will join Boston University for a new postdoc position to fight COVID-19.
June 11, 2020- Guangping's paper on "Optimization of high-throughput methyltransferase assays for the discovery of small molecule inhibitors" has been accepted for publication in ACS Combinatorial Science. This is a team work with NCATS. Congratulation. https://pubs.acs.org/doi/10.1021/acscombsci.0c00077
May 27, 2020-Congratulate to Dr. Huang who has been appointed as a Purdue University Faculty Scholar. An additional congratulation to being selected as a 2020 Showalter Faculty Scholar. Thanks for the support from MCMP department and College of Pharmacy.
May 13, 2020-Congratulate to Ying who passed her OP to be a PhD candidate now.
May 11, 2020-Congratulate to Ayad and Krystal whose review is in press now. 10.2174/1389203721666200507091952.
April 27, 2020-Farewell to Dr. Zhi Huang who will join UNC for his new postdoc position.
February 26, 2020- We are hiring a new postdoc fellow.
link: https://career8.successfactors.com/sfcareer/jobreqcareer?jobId=9952&company=purdueuniv&username=
February 21, 2020 - We thank NIGMS for a research diversity supplement to fund our first year graduate student Krystal Diaz for 18 months.
December 19, 2019- Congratulate to Guangping who passed his OP to be a PhD candidate now.
December 10, 2019- Welcome two MCMP graduate students Amr and Krystal to join Huang lab.
November 13, 2019-Another J Med Chem paper has just been accepted today. Congratulation to Dongxing, Linjie, Krystal, and Iredia! Special appreciation to our great collaborators Dr. Nick Noinaj and his student Ravi Yadav!
October 24, 2019- Welcome Dr. Nazimuddin from University of Louisville joining our group.
October 17, 2019-Dr. Huang gave a talk at the Department of Medicinal & Biological Chemistry in University of Toledo.
October 4, 2019-Dr. Huang presented our work on protein N-terminal methylation at 2019 Protein N-termini meeting. Enjoyed the interactions in the protein N-terminal community.
September 24, 2019- Welcome Amr Elkabbany to do his 2nd rotation in the lab.
September 23, 2019- Dr. Huang gave a talk at the Department of Biochemistry and Molecular Biology in Indiana University School of Medicine.
September 2, 2019- Dr. Huang gave a talk at Baylor Medical College Department of Pharmacology & Chemical Biology.
September 2, 2019- Welcome Dr. Youchao Deng from Central South University joining our group.
August 26, 2019- Welcome Krystal to do her 1st rotation in the lab.
August 9, 2019- Our first lab retreat is a blast with various research presentations followed by hiking and kayaking.
August 5, 2019- Welcome Dr. Zhi Huang from Naikai University joining our group.
July 1, 2019 - We thank NIGMS for a supplementary award to purchase a live cell imager to boost our cell-based studies.
June 3, 2019 - Dr. Dongxing Chen presents his work on potent and selective NTMT1 inhibitors at Gordon Research Conference on High Throughput Chemistry and Chemical Biology.
May 1, 2019- Welcome Dr. Iredia D. Iyamu from Northwestern University joining our group.
April 30, 2019- Congratulation to our undergraduate student Yuanrui Zhao who has been selected as a recipient for the OUR Scholars Program.
April 15, 2019- Congratulation to visiting student Congyu Zhang who has been accepted to the PK/PD Master program in University of Buffalo in Fall 2019.
March 18, 2019 - Congratulation to Dongxing and Guangping whose first co-author paper titled "Discovery of bisubstrate inhibitor for protein N-terminal methyltransferase 1" has been accepted for publication in the Journal of Medicinal Chemistry. pubs.acs.org/doi/10.1021/acs.jmedchem.9b00206
January 25, 2019 - Congratulation to Krystal who has been admitted to MCMP PhD program starting in Fall, 2019.
January 14, 2019 - Welcome Congyu Zhang from Shenyang Pharmaceutical University and Yuanrui Zhang from Purdue University to do their undergraduate research in Huang lab.
December 5, 2018- Happy to welcome our new MCMP PhD students Ying Meng and Yi-Hsun Ho to the Huang Lab.
November 26, 2018- Dr. Huang's invited review titled "Chemical Biology of Protein N-terminal Methyltransferases" is in press in the ChemBioTalents Issue of ChemBiochem. onlinelibrary.wiley.com/doi/10.1002/cbic.201800615
November 2, 2018 -Guangping's co-first author paper on NTMT2 structure is in press now. https://www.nature.com/articles/s42003-018-0196-2
October 29, 2018 - Congratulation to Dr. Huang on her 2018 Purdue University Seed for Success Award
October 15, 2018 - Congratulation to Guangping whose first co-author paper on NTMT2 structure has been accepted for publication in Communications Biology.
October 2, 2018 - Welcome Krystal from Penn State Univ joining Huang lab as a lab technician.
August 6, 2018 - Congratulate to Pahul, our undergraduate alumnus, who just started her MD/PhD study at Univ. of Texas at Houston.
July 2, 2018 - Dr. Huang gave an invited talk at Huazhong Technology & Science University.
June 28, 2018 - Dr. Huang gave a seminar at Peking University School of Pharmaceutical Sciences, China.
June 26, 2018 - Dr. Huang gave an invited talk at Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, China.
June 19, 2018 - Our proposal of Discovery of Small Molecule Inhibitors for N-terminal Acetyltransferase D has received the Purdue Institute for Drug Discovery’s Hit to Lead Program’s High-Throughput/High-Content Chemical Genomics Screening Facility Fund. Thanks for the support and we are excited about a new adventure.
June 11, 2018 - Another co-crystal structure of our inhibitor in complex with NTMT1. Hooray for Dongxing and Nick!
May 17, 2018 - Our first provisional patent application on protein N-terminal methyltransferase peptidomimetic inhibitors has been successfully filed. Congratulate to Dongxing and Guangping! inventions.prf.org/innovation/6782
April 24, 2018 - Congratulation to Dongxing who obtained crystal structures with two of our inhibitors. Appreciate our collaborator Nick for his great effort. Can't wait to see the final structures.
March 16, 2018 - Very proud of Pahul who did her undergraduate studies with us for three years and continues to be successful. https://news.vcu.edu/article/In_Norway_Fulbright_scholar_Pahul_Hanjra_is_furthering_our_understanding?utm_source=VCUNewsNewsletter&utm_medium=email&utm_campaign=VCUNewsNewsletter&utm_content=news.vcu.edu%2Farticle%2FIn_Norway_Fulbright_scholar_Pahul_Hanjra_is_furthering_our_understanding
January 10, 2018 - Welcome Mr. Nathan J Becker joining our lab to carry his undergraduate research.
January 8, 2018 - Welcome Dr. Ayad Al-Hamashi joining our lab from University of Toledo.
August 18, 2017 - Dr. Huang has received a U01 grant from the National Cancer Institute. Thanks for the support and our collaborators at NCATS!
August 16, 2017 - We are recruiting for Two Postdoctoral Research Associate Positions. Details see www.nature.com/naturejobs/science/jobs/621777-postdoctoral-research-associate
August 15, 2017 - Linjie, Dongxing, and Guangping presented their research at PULSe retreat.
July 3, 2017 - Huang lab has moved to the 2nd floor of Purdue Institute of Drug Discovery at Purdue University.