research

​​Huang lab applies a multidisciplinary approach to elucidate the mechanisms and functions of epigenetic modifications including methylation and acetylation to develop novel therapeutic agents for cancer, metabolic, infectious, and neurodegenerative diseases; rational designs and synthesize selective and potent inhibitors for methyltransferases and acetyltransferases; develop HTS assay and efficiently create compounded libraries to screen lead compounds.

research projects

Strategies to build MTase bisubstrate analogs: PMID:32605369; PMID: 30883119​; PMID:30883119​; 
Adenosine analog library: PMID:  39361813

Available MTase Inhibitors:
   Protein N-terminal MTase 1/2 (NTMT1/2): DC541 (acs med chem letts); GD562; GD433 (PMID: 36634151)
   Nicotinamide N-MTase (NNMT): LL320 (PMID: 31724854); II399 (PMID: 35134268); II559 and II802 (PMID: 37523719); II630; II679
   Protein arginine methyltransferases (PRMTs): YD1342 (selective and potent PRMT4 inhibitor in cellular and animal models; PMID:  39361813)
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​  Available Protein N-terminal acetyltransferase (NAT) inhibitors
   NatD: YD612 (PMID:34110812)

collaboration

Huang Lab is always open to collaborative opportunities. If you are interested, please contact Dr. Rong Huang at huang-r at purdue dot edu.