HUANG LAB
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research

​​Huang lab applies a multidisciplinary approach to elucidate the mechanisms and functions of epigenetic modifications including methylation and acetylation to develop novel therapeutic agents for cancer, metabolic, infectious, and neurodegenerative diseases; rational designs and synthesize selective and potent inhibitors for methyltransferases and acetyltransferases; develop HTS assay and efficiently create compounded libraries to screen lead compounds.

research projects

Project 1: Targeting Methyltransferases (NTMTs, NNMT, and PRMTs) to discover new drugs
​   Available Methyltransferase Inhibitors:
   Protein n-terminal MTase 1/2 (NTMT1/2): DC541 (acs med chem letts); GD562; GD433 (pmid: 36634151)
   Nicotinamide N-MTase (NNMT): LL320 (pmid: 31724854); II399 (pmid: 35134268); II559; II802; II630

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​Project 2: Targeting Protein α-N-terminal Acetylation
​   Available Protein N-terminal acetyltransferase (NAT) inhibitors
   NatD: YD612 (pmid:34110812)

collaboration

Huang Lab is always open to collaborative opportunities. If you are interested, please contact Dr. Rong Huang at huang-r at purdue dot edu.

Research is funded by:

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Made in 2023   |    Created by Eric Yu

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